Peptide Name
Melanotan II (MLT-2)
Peptide Class
Synthetic melanocortin peptide analog; cyclic peptide
Amino Acid Sequence
Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
(lactam cyclization between Asp and Lys side chains)
Molecular Formula
C₅₀H₆₉N₁₅O₉
Molecular Weight
~1024.2 g/mol
Peptide Type
Cyclic peptide (lactam-bridged), N-terminally acetylated, C-terminal amide
Chemical Structure
Cyclic heptapeptide analog containing norleucine (Nle) and D-phenylalanine; macrocycleformed via an intramolecular amide (lactam) bond between aspartic acid and lysine sidechains. No glycosylation or additional post-translational modifications.
Solubility
Generally soluble in water and common aqueous laboratory buffers; solubility depends on pH,ionic strength, and peptide concentration.
Stability Characteristics
Lyophilized form: Store dry, protected from light and moisture, at−20 °C or below for long-termstability.
Reconstituted solutions: Prepare under sterile conditions; store in aliquots at cold temperaturesand avoid repeated freeze–thaw cycles. Stability is buffer- and pH-dependent.
Source Classification
Synthetic (solid-phase peptide synthesis with controlled cyclization)
Purity Specification
≥98% (HPLC-verified)
Identity confirmed by mass spectrometry
Batch-specific Certificate of Analysis (COA) available
